The Scientific Side of Steroid Use and AbuseAndrogenic-anabolic steroids AAS are synthetic derivatives of the male hormone testosterone. They can exert strong effects on the human body that trenbolone acetate u.s.p be beneficial studies on anabolic steroids athletic performance. A review of the literature revealed that most laboratory studies did not investigate the actual doses of AAS currently abused in the field. Therefore, those studies may not reflect the actual adverse effects of steroids. The available scientific literature describes that short-term administration of these drugs by athletes can studies on anabolic steroids strength and bodyweight. A reduction of fat mass does not seem to occur. Although AAS administration may affect erythropoiesis and blood haemoglobin concentrations, no effect on endurance performance was observed.
Medical Issues Associated with Anabolic Steroid Use: Are They Exaggerated?
Revised April, Public Domain. Since the s, some athletes have been taking anabolic steroids to build muscle and boost their athletic performance. Increasingly, other segments of the population also have been taking these compounds. The Monitoring the Future study, which is an annual survey of drug abuse among adolescents across the country, showed a significant increase from to in steroid abuse among middle school students.
During the same year, the percentage of 12th-graders who believed that taking these drugs causes "great risk" to health, declined from 68 percent to 62 percent. The abuse of oral or injectable steroids is associated with higher risks for heart attacks and strokes, and the abuse of most oral steroids is associated with increased risk for liver problems. Anabolic steroid abuse can also cause undesirable body changes. These include breast development and genital shrinking in men, masculinization of the body in women, and acne and hair loss in both sexes.
These and other effects of steroid abuse are discussed in this Research Report, which is one of a series of reports on drugs of abuse. NIDA produces this series to increase understanding of drug abuse and addiction and the health effects associated with taking drugs. We hope that this compilation of scientific information on anabolic steroids will help the public recognize the risks of steroid abuse. Director National Institute on Drug Abuse.
They promote the growth of skeletal muscle anabolic effects and the development of male sexual characteristics androgenic effects , and also have some other effects. The term "anabolic steroids" will be used through-out this report because of its familiarity, although the proper term for these compounds is "anabolic-androgenic" steroids. Anabolic steroids were developed in the late s primarily to treat hypogonadism, a condition in which the testes do not produce sufficient testosterone for normal growth, development, and sexual functioning.
The primary medical uses of these compounds are to treat delayed puberty, some types of impotence, and wasting of the body caused by HIV infection or other diseases. During the s, scientists discovered that anabolic steroids could facilitate the growth of skeletal muscle in laboratory animals, which led to use of the compounds first by bodybuilders and weightlifters and then by athletes in other sports.
Steroid abuse has become so widespread in athletics that it affects the outcome of sports contests. More than different anabolic steroids have been developed, but they require a prescription to be used legally in the United States.
Most steroids that are used illegally are smuggled in from other countries, illegally diverted from U. In the United States, supplements such as dehydroepian-drosterone DHEA and androstenedione street name Andro can be purchased legally without a prescription through many commercial sources including health food stores. They are often referred to as dietary supplements, although they are not food products.
They are often taken because the user believes they have anabolic effects. Steroidal supplements can be converted into testosterone an important male sex hormone or a similar compound in the body. Whether such conversion produces sufficient quantities of testosterone to promote muscle growth or whether the supplements themselves promote muscle growth is unknown. Little is known about the side effects of steroidal supplements, but if large quantities of these compounds substantially increase testosterone levels in the body, they also are likely to produce the same side effects as anabolic steroids.
Recent evidence suggests that steroid abuse among adolescents is on the rise. The Monitoring the Future study, a NIDA-funded survey of drug abuse among adolescents in middle and high schools across the United States, estimated that 2. For 10th-graders, that is a significant increase from , when 2. For all three grades, the levels represent a significant increase from , the first year that data on steroid abuse were collected from the younger students.
In that year, 1. Few data exist on the extent of steroid abuse by adults. It has been estimated that hundreds of thousands of people aged 18 and older abuse anabolic steroids at least once a year. Among both adolescents and adults, steroid abuse is higher among males than females. However, steroid abuse is growing most rapidly among young women. One of the main reasons people give for abusing steroids is to improve their performance in sports.
Among competitive bodybuilders, steroid abuse has been estimated to be very high. Among other athletes, the incidence of abuse probably varies depending on the specific sport. This group includes some people who have a behavioral syndrome muscle dysmorphia in which a person has a distorted image of his or her body.
Men with this condition think that they look small and weak, even if they are large and muscular. Similarly, women with the syndrome think that they look fat and flabby, even though they are actually lean and muscular.
Some people who abuse steroids to boost muscle size have experienced physical or sexual abuse. They are trying to increase their muscle size to protect themselves. In one series of interviews with male weightlifters, 25 percent who abused steroids reported memories of childhood physical or sexual abuse, compared with none who did not abuse steroids.
Moreover, almost all of those who had been raped reported that they markedly increased their bodybuilding activities after the attack. They believed that being bigger and stronger would discourage further attacks because men would find them either intimidating or unattractive. Finally, some adolescents abuse steroids as part of a pattern of high-risk behaviors.
These adolescents also take risks such as drinking and driving, carrying a gun, not wearing a helmet on a motorcycle, and abusing other illicit drugs. While conditions such as muscle dysmorphia, a history of physical or sexual abuse, or a history of engaging in high-risk behaviors may increase the risk of initiating or continuing steroid abuse, researchers agree that most steroid abusers are psychologically normal when they start abusing the drugs.
Some anabolic steroids are taken orally, others are injected intramuscularly, and still others are provided in gels or creams that are rubbed on the skin. Doses taken by abusers can be 10 to times higher than the doses used for medical conditions. Abusers think that the different steroids interact to produce an effect on muscle size that is greater than the effects of each drug individually, a theory that has not been tested scientifically.
Often, steroid abusers also "pyramid" their doses in cycles of 6 to 12 weeks. At the beginning of a cycle, the person starts with low doses of the drugs being stacked and then slowly increases the doses. In the second half of the cycle, the doses are slowly decreased to zero. This is sometimes followed by a second cycle in which the person continues to train but without drugs. As with stacking, the perceived benefits of pyramiding and cycling have not been substantiated scientifically.
Anabolic steroid abuse has been associated with a wide range of adverse side effects ranging from some that are physically unattractive, such as acne and breast development in men, to others that are life threatening, such as heart attacks and liver cancer. Most are reversible if the abuser stops taking the drugs, but some are permanent. Most data on the long-term effects of anabolic steroids on humans come from case reports rather than formal epidemiological studies.
From the case reports, the incidence of life-threatening effects appears to be low, but serious adverse effects may be under-recognized or under-reported. Data from animal studies seem to support this possibility. One study found that exposing male mice for one-fifth of their lifespan to steroid doses comparable to those taken by human athletes caused a high percentage of premature deaths. Steroid abuse disrupts the normal production of hormones in the body, causing both reversible and irreversible changes.
Changes that can be reversed include reduced sperm production and shrinking of the testicles testicular atrophy. Irreversible changes include male-pattern baldness and breast development gynecomastia. In one study of male bodybuilders, more than half had testicular atrophy, and more than half had gynecomastia. Gynecomastia is thought to occur due to the disruption of normal hormone balance.
In the female body, anabolic steroids cause masculinization. Breast size and body fat decrease, the skin becomes coarse, the clitoris enlarges, and the voice deepens. Women may experience excessive growth of body hair but lose scalp hair. With continued administration of steroids, some of these effects are irreversible. Rising levels of testosterone and other sex hormones normally trigger the growth spurt that occurs during puberty and adolescence.
Subsequently, when these hormones reach certain levels, they signal the bones to stop growing, locking a person into his or her maximum height. When a child or adolescent takes anabolic steroids, the resulting artificially high sex hormone levels can signal the bones to stop growing sooner than they normally would have done. Steroid abuse has been associated with cardiovascular diseases CVD , including heart attacks and strokes, even in athletes younger than Steroids contribute to the development of CVD, partly by changing the levels of lipoproteins that carry cholesterol in the blood.
Steroids, particularly the oral types, increase the level of low-density lipoprotein LDL and decrease the level of high-density lipoprotein HDL. High LDL and low HDL levels increase the risk of atherosclerosis, a condition in which fatty substances are deposited inside arteries and disrupt blood flow. If blood is prevented from reaching the heart, the result can be a heart attack. If blood is prevented from reaching the brain, the result can be a stroke. Steroids also increase the risk that blood clots will form in blood vessels, potentially disrupting blood flow and damaging the heart muscle so that it does not pump blood effectively.
Steroid abuse has been associated with liver tumors and a rare condition called peliosis hepatis, in which blood-filled cysts form in the liver. Both the tumors and the cysts sometimes rupture, causing internal bleeding. Many abusers who inject anabolic steroids use nonsterile injection techniques or share contaminated needles with other abusers. In addition, some steroid preparations are manufactured illegally under non-sterile conditions. These factors put abusers at risk for acquiring life-threatening viral infections, such as HIV and hepatitis B and C.
Abusers also can develop infective endocarditis, a bacterial illness that causes a potentially fatal inflammation of the inner lining of the heart. Bacterial infections also can cause pain and abscess formation at injection sites.
Case reports and small studies indicate that anabolic steroids, particularly in high doses, increase irritability and aggression. Some steroid abusers report that they have committed aggressive acts, such as physical fighting, committing armed robbery, or using force to obtain something. Abusers who have committed aggressive acts or property crimes generally report that they engage in these behaviors more often when they take steroids than when they are drug-free.
According to this theory, the abusers are using this possible link as an excuse to commit aggressive acts and property crimes. One way to distinguish between these two possibilities is to administer either high steroid doses or placebo for days or weeks to human volunteers and then ask the people to report on their behavioral symptoms.
To date, four such studies have been conducted. In three, high steroid doses did produce greater feelings of irritability and aggression than did placebo; but in one study, the drugs did not have that effect. One possible explanation, according to researchers, is that some but not all anabolic steroids increase irritability and aggression. Anabolic steroids have been reported also to cause other behavioral effects, including euphoria, increased energy, sexual arousal, mood swings, distractibility, forgetfulness, and confusion.
In the studies in which researchers administered high steroid doses to volunteers, a minority of the volunteers developed behavioral symptoms that were so extreme as to disrupt their ability to function in their jobs or in society.