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The Ultimate Guide to SARMs
Selective Androgen Receptor Modulators? The topic of SARMs or selective androgen receptor modulators have been a controversial one since the early 90s when they were first introduced in mainstream science. In the s, steroidal SARMs have been used for medical use in multiple diseases including cancer, hypogonadism, osteoporosis, and a number of other diseases that affect muscle and bone wasting. Unfortunately, steroidal SARMs came with side effects such as estrogen conversion causing gynecomastia puffy sensitive nipples in men , decreased libido, and damage to the liver and kidneys related to its methylation.
Another side effect was that steroids can change the DNA of multiple cells such as the prostate and heart cause them to enlarge. In the early s, scientist created a non-steroidal version of these SARMs by making them protein based.
The difference between these two types of SARMs is most easily described as a lock and key system. The cells in the body act as locks and the binding sites of the cells are like key holes. Nonsteroidal SARMs are designed specifically for one type of lock, therefore, it will only affect areas of the DNA that prevent muscle and bone wastage while also promoting growth in these areas. Nonsteroidal SARMs have been used for bodybuilding, powerlifting and a multitude of other sports since the start of it popularity.
Their benefit to side effect ratio have been tested since the s with no evidence suggesting harm. This breakthrough in scientific technology continues to suggest SARMs is the future of anabolics and will eventually replace steroid therapy.
Now this is not to say that nonsteroidal SARMs are the answers to all our problems. Although a protein based SARMs have very limited side effects with large benefits for strength and muscle gains, they also require a much longer period of use and cannot yet compare to the effectiveness of a steroid. The comparison of benefits and unwanted side effects have been researched for decades. Unlike testosterone cypionate, SARMS are more than times more powerful in muscle stimulation and 80 times more selective for muscle.
Prohormones were the first ones introduced to the market. It can be administered orally, minimizing the effects in testosterone blood levels. SARMS are also believed to cure various diseases which steroids and other medicines treated earlier. It also shows promise to replace androgen which can yield similar desirable results on muscle tissue as steroids. According to a study conducted by the World Anti-doping Agency WADA , approximately tenth of the worlds athletic population uses SARMS particularly Ostarine to enhance their body and performance which is considered a safe performance boost.
Studies have shown the ability of SARMs to increase muscle and bone mass dramatically in animals while having no adverse impact on the prostate. Ostarine or MK As we age, our endurance, power and skeletal muscle mass deteriorates due to the loss of type 2 muscle fibers. This hinders individuals to function normally. The anabolic effect is expected to be the same as testosterone. SARMS link to the same receptors that old steroids such as Dianabol and testosterone would connect to, but minus the drawbacks and side effects of traditional steroids and prohormones.
This is a fresh start in the advancement of muscle pharmacology as SARMS can help enhance muscle mass, while helping you reduce body fat and boost athletic performance beyond your imagination. SARMS is believed to have the capacity to employ the benefits of anabolic supplements while reducing the side effects of steroids. In the Asian Journal of Andrology, subjects increased muscle strength 20x more than those in the placebo group.
Subjects continued to gain strength and size in muscle tissue for up to 5 months but with significant decreases in effectiveness after the 3rd month Dalton et al, Deductive evidence has proven a significant increase in muscle tissue hypertrophy growth of muscle tissue. Inductive evidence suggests subjects will gain between 3 to 15 lbs of muscle tissue over the a 12 week period Dubois et al, The amount of muscle hypertrophy is dependent on diet, training, and the characteristics of the SARM.
Unlike other anabolic agents, non steroidal SARMs do not affect any other tissues in the body Dubois et al, Androgen receptors are known to play a pivotal role in the treatment of breast cancer and due to the inability for nonsteroidal SARMs to convert to estrogen, there is a very narrow probability for negative repercussions. Recent studies have indicated healthy increases in sexual desire in both men and women with the use of nonsteroidal SARMs.
The males with hypogonadism, testosterone therapy is a common practice. In testosterone therapy there are many side effects that result is severe consequences for the user, such as thickening of the blood commonly causing strokes and heart attacks , enlargement or development of cancer on the prostate, and gynecomastia characterized as the development of female breast on men due to an overproduction of estrogen.
In the Journal of Pharmacology and Experimental Therapeutics, Researcher reported positive effects of nonsteroidal SARMs on females with low sexual motivation indicating noticeable increases in sexual desire Jones et al, Results were favorable indicated by hormone and lipid levels returning to normal without the use of a post cycle therapy.
No dangers were detected throughout the study. If you overdo it, however, some people may experience shut down or even gynecomastia if currently predisposed to it. Be responsible, and in Current research has so far agreed with that conclusion. There are many manufacturers selling SARMs online right now.
Although they are not legal for human consumption, you can buy them from many research labs to experiment with your rat. In fact, as of January 8th of this year, their popularity all over reddit and solid reputation caused them to upgrade to a bigger facility.
You can check out their homepage for a selection of SARMs and other useful compounds. When it comes to SARMs, many people stack more than 1 at a time to maximize their results even further. This is a capsule containing 5 different SARMs in one. Liquid SARMs are harder to stack because of the pure taste and inconvenience of having to measure it out multiple times a day.
Plus it tends to be much more expensive. With SARMS showing great promise for selective high anabolic muscle activity and in preventing muscle wasting and age related illnesses without the negative side effects associated with anabolic steroids and prohormones, SARMS could be the next big thing. Richard Lyttle, Louis St. Compton, Bishwabhusan Sahoo, Sean A. Burge, Michael Nickels, Jennifer L. Katzenellenbogen, Alexei Tchesnokov, and Gary Hattersley. American Chemical Society, 10 Feb.
Laurent, Ferran Jardi, Philippa T. Saunders, Dirk Vanderschueren, and Frank Claessens. Oxford University Press, 01 Dec. National Library of Medicine, Dec. Basaria, Shehzad, Lauren Collins, E.
Biological Sciences and Medical Sciences. Oxford University Press, Jan. National Library of Medicine, 25 June Steiner, and James T. Cheney, Muralimohan Yepuru, Duane D. Mesenchymal Stem Cell Signaling. Public Library of Science, Jayaraman, Anusha et al. Since I will not complain about lean gains , I would like to know which SARM would be best for a 48 year-old man who recently had a heart attack.
I need something to build muscle and get strong …so I find MK one of my friend told me to use it…he said it really works so im going try it. You should tell your rats to take it along with your shake! I have hypothyroidism so just wondering if there are any sarms that I should not take. Someone please respond to this. I want put on lean muscle. Strength and burn off stubborn belly fat. I am taking 40 mgs Lipatordaily, mg Test cyapinate weekly for muscle loss.
What would you suggest as a sarms stack that is safe with the Lipator? Taking 40mgs Lipator daily. I need to make sure there is no muscle loss. Last updated Jan 9, Dr adarsh says 2 years ago.
Take tab niacin vitamin B6 1gm tds fr 6 wks if u dont have any bleeding tendency. James H says 12 months ago. Stephanie Watts says 2 years ago. Are there any studies long-term or otherwise on the effects of these products on women? Paul Gianni says 1 year ago. Robert Johnson DC says 1 year ago. Margaret Gillespie says 1 year ago. David Norman says 12 months ago.
SARMS are great but my rat doesnt like the taste of the liquid kind. Any help with that? Sealey says 11 months ago. Nutrition says 10 months ago. Ben Brown says 11 months ago. Phoenix23 says 10 months ago.